Post Doctoral Scientist - Extracellular Vesicles/Fibrosis

Dr. David Brigstock's lab. We are interested in mechanisms underlying the development of liver fibrosis which is a common feature of alcohol-associated liver disease, metabolic dysfunction associated fatty liver disease, viral hepatitis, liver cirrhosis and cancer. We are particularly interested in how extracellular vesicles (EVs) control this process and how various populations of EVs can be leveraged for therapy.

The postdoc is expected to take a lead role in a project involving the production and action of EVs in single cell and liver organoid models of AALD and MASLD. The project will involve EV isolation, genetic manipulation to follow EV trafficking and biological effects, microscopy, omics studies, network analysis, and a full slate of molecular and cell biology techniques.

• Designs experiments, develops protocols, and conducts research under the guidance of a faculty mentor.
• Assists in the training and supervision of technical support staff in performing specific techniques essential to carrying out the research program.
• Records and analyzes data generated by the research study. Assists in the development of hypotheses for further investigation from the results of the studies performed.
• Assists with the preparation of scientific and technical papers for publication in peer-reviewed journals. Presents findings at local and national research forums.
• Collaborates with other ongoing research efforts either at NCH or at The Ohio State University.
• Works toward research independence, preparing to submit proposals to and obtain funding from external granting agencies.

PhD or equivalent degree in relevant field of science, required.

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• Effective interpersonal skills required in interactions with scientists, physicians, and laboratory colleagues.
• Excellent laboratory technical skills.
• Excellent computer skills.
• Skills in qualitative and quantitative research methods.
• Ability to proactively manage and drive projects.

Research experience from PhD program, required.

OCCASIONALLY: Bend/twist, Climb stairs/ladder, Lifting / Carrying: 11-20 lbs

FREQUENTLY: Lifting / Carrying: 0-10 lbs, Standing, Walking

CONTINUOUSLY: Audible speech, Color vision, Computer skills, Decision Making, Depth perception, Flexing/extending of neck, Hand use: grasping, gripping, turning, Hearing acuity, Interpreting Data, Peripheral vision, Problem solving, Reaching above shoulder, Repetitive hand/arm use, Seeing - Far/near, Sitting, Squat/kneel

Pressure in this position will vary depending on the workload. The workload will be heavy but manageable most of the time. Pressure may arise in the face of deadlines associated research and manuscript writing.

"The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individuals so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under their supervision. EOE M/F/Disability/Vet"