Pharmacology Research Scientist

Job Description

General Summary:

We are seeking a talented, self-motivated and collaborative in-vivo pharmacologist to join the integrated pharmacology team supporting late-stage drug discovery. The ideal candidate will have a strong foundation in pharmacology, work with a high degree of independence and be adept at conceptually designing, executing and interpreting in vivo/ex vivo experiments to establish therapeutic proof-of-concept across diverse disease areas.

Key Duties and Responsibilities:

• Designs and conducts elaborate, conceptually connected, multi-component in vivo/ex vivo experiments to demonstrate proof-of-concept in preclinical disease models including pharmacokinetic, pharmacodynamic and efficacy relationships.
• Perform advanced and/or complex experimental assay development and troubleshooting.
• Collates and interprets complex data systematically and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities.
• Exercises solid judgment to prioritize studies, considering feasibility and Project impact.
• Scours relevant scientic literature and routinely incorporates new insights into research activities.
• Identies, prioritizes and introduces relevant emerging technologies in their eld of expertise to advance the existing technology platforms and create/maintain a competitive advantage.
• Explores the feasibility of applying new scientic principles/concepts or implements and validates novel experimental approaches and technologies to achieve project goals.
• Contributes signicantly to patent and/or publication preparation.
• Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings.
• Performs other duties as assigned.

Knowledge and Skills:

• Designs and executes complex, well controlled, challenging experiments that measure the action of compounds on in vivo/ex vivo disease biology assays.
• Maintains a broad working knowledge of fundamental pharmacology principles.
• Demonstrates astute understanding of his/her own discipline and the relevant literature.
• Maintains a high level of knowledge related to current developments in the scientic Project eld.
• Displays proven productivity and experimental creativity, and effective dissemination of ideas.
• Demonstrates effective, self-sufcient communication skills, especially in peer-directed presentations.
• Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas.
• Must be proficient in rodent handling, dosing (IV, PO, IP, SC), blood collection (tail nick, submandibular, cardiac puncture) and tissue harvesting.
• Demonstrate experience developing, executing and troubleshooting assays across a wide array of in vivo and molecular techniques (i.e. ELISA, qPCR, Western and flow cytometry).
• Ability to rapidly learn and master new techniques and technologies.
• Essential qualities include: integrity, flexibility, adaptability, organization and multi-tasking skills, excellent record keeping and the ability to function both independently and effectively as part of an interactive and cross-functional team.

Education and Experience:

• Bachelor's degree in pharmacology or related biological sciences
• Typically requires a PhD and 0-3 years of experience or,
• Typically requires a Masters degree and 3 years of experience or,
• Typically requires a Bachelors degree and 6 years of experience

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com